Tangeretin improves hepatic steatosis and oxidative stress through the Nrf2 pathway in high fat diet-induced nonalcoholic fatty liver disease mice
Zunli Ke, Si Tan, Haiyang Li, Shanshan Jiang, Yuping Li, Rui Chen, Mingxia Li
Abstract
. Furthermore, the expression of the hepatic nucleus, Nrf2, HO-1 and GCLC, was also seen to be significantly enhanced in WB analysis. Taken together, this study implies that tangeretin might alleviate NAFLD through lowering oxidative stress in the liver by partial modulation of the Nrf2 pathway. Our study provided theoretical support that tangeretin could be used as a dietary therapy for obesity related-NAFLD or related metabolic syndrome.
Topics & Concepts
Nonalcoholic fatty liver diseaseSteatosisOxidative stressMetabolic syndromeInternal medicineEndocrinologyMedicineFatty liverObesityDiseaseLiver Disease Diagnosis and TreatmentGenomics, phytochemicals, and oxidative stressBiochemical effects in animals