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Novel [(<i>N</i>-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and <i>in silico</i> studies

Tarfah Al‐Warhi, Mahmoud F. Abo-Ashour, Hadia Almahli, Ohoud J. Alotaibi, Mohammad M. Al‐Sanea, Ghada H. Al-Ansary, Hanaa Y. Ahmed, Mahmoud M. Elaasser, Wagdy M. Eldehna, Hatem A. Abdel‐Aziz

2020Journal of Enzyme Inhibition and Medicinal Chemistry65 citationsDOIOpen Access PDF

Abstract

as a promising lead for further development and optimisation as an efficient antitumor drug.

Topics & Concepts

IsatinCell cycle checkpointCell cycleChemistryApoptosisCyclin-dependent kinase 2StereochemistryG1 phaseFlow cytometryAnnexinCell growthKinaseBiochemistryMolecular biologyBiologyOrganic chemistrySynthesis and biological activityCancer therapeutics and mechanismsSynthesis and Characterization of Heterocyclic Compounds
Novel [(<i>N</i>-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and <i>in silico</i> studies | Litcius