Elemental Sulfur-Mediated Synthesis of Quinoxalines from Sulfoxonium Ylides
Trayambek Nath Chaubey, Paran J. Borpatra, Satyendra Kumar Pandey
Abstract
A novel straightforward and catalyst-free approach for synthesizing quinoxaline derivatives from sulfoxonium ylides and o -phenylenediamines mediated by elemental sulfur has been described. Due to the simple and mild reaction conditions, the sulfoxonium ylides and o -phenylenediamines decorated with different functional groups furnished moderate to high yields of quinoxaline derivatives and were well tolerated. Finally, large-scale reactions, the synthesis of pyrazines, and some bioactive compounds are used to illustrate the potential utility of the developed approach.
Topics & Concepts
QuinoxalineChemistrySulfurCatalysisCombinatorial chemistryOrganic chemistryReaction conditionsSynthesis and Biological EvaluationSulfur-Based Synthesis TechniquesCyclopropane Reaction Mechanisms