ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling
Hüseyin Tayran, Elanur Yılmaz, Prabesh Bhattarai, Yuhao Min, Xue Wang, Yiyi Ma, Ni Wang, Inyoung Jeong, Nastasia Nelson, Nada Kassara, Mehmet İlyas Coşacak, Rüya Merve Dogru, Dolly Reyes‐Dumeyer, Jakob Mørkved Stenersen, Joseph S. Reddy, Min Qiao, Delaney Flaherty, Tamil Iniyan Gunasekaran, Zikun Yang, Nathalie Jurisch‐Yaksi, Andrew F. Teich, Takahisa Kanekiyo, Giuseppe Tosto, Badri N. Vardarajan, Özkan İş, Nilüfer Ertekin‐Taner, Richard Mayeux, Çağhan Kızıl
Abstract
suppresses NPY. Clinical data showed reduced NPY in AD correlated with elevated Braak stages, genetic variants in NPY associated with AD, and epigenetic changes in NPY, NGFR, and BDNF promoters linked to ABCA7 variants. Therefore, ABCA7-dependent NPY signaling via BDNF-NGFR maintains synaptic integrity, implicating its impairment in increased AD risk through reduced brain resilience.