Harnessing UBR5 for targeted protein degradation of key transcriptional regulators
Asad M. Taherbhoy, Danette L. Daniels
Abstract
Targeted protein degradation (TPD) has opened the door for drugging transcriptional regulators, yet the number of proteins targeted and E3 ligases utilized remain limited. Here, we highlight UBR5 and propose multiple strategies by which this E3 ligase could be modulated to drive degradation of key transcriptional targets implicated in disease.
Topics & Concepts
Ubiquitin ligaseUbiquitinProtein degradationDegradation (telecommunications)Key (lock)Ubiquitin-Protein LigasesComputational biologyCell biologyBiologyComputer scienceGeneticsGeneTelecommunicationsEcologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research