Clinical <i>Candida albicans</i> Vaginal Isolates and a Laboratory Strain Show Divergent Behaviors during Macrophage Interactions
Franziska Gerwien, Christine Dunker, Philipp Brandt, Enrico Garbe, Ilse D. Jacobsen, Slavena Vylkova
Abstract
Vulvovaginal candidiasis is one of the most common fungal infections in humans with Candida albicans as the major causative agent. This study is the first to compare clinical vaginal isolates of defined patient groups in their interaction with macrophages, highlighting the vastly different outcomes in comparison to a laboratory strain using commonly applied virulence-determining assays.
Topics & Concepts
Candida albicansVirulenceVulvovaginal CandidiasisMicrobiologyStrain (injury)Corpus albicansMacrophageBiologyVaginaIn vitroGeneticsGeneAnatomyAntifungal resistance and susceptibilityReproductive tract infections researchFungal Infections and Studies