Colchicine selective interaction with oncogene <i>RET</i> G-quadruplex revealed by NMR
Fei Wang, Chunxi Wang, Yaping Liu, Wenxian Lan, Hao Han, Renxiao Wang, Shaohua Huang, Chunyang Cao
Abstract
G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.
Topics & Concepts
ColchicineG-quadruplexOncogeneChemistryDNACancer researchStereochemistryRET proto-oncogeneSmall moleculeCombinatorial chemistryComputational biologyBiologyBiochemistryGeneticsMutationGeneGermline mutationCell cycleDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery