Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects
Yasmeen T. AlNajjar, Moustafa T. Gabr, Ahmed K. ElHady, Mohamed Salah, Gerrit Wilms, Alireza Abadi, Walter Becker, Mohammad Abdel‐Halim, Matthias Engel
Topics & Concepts
DYRK1AChemistryHarmineNeuroprotectionIC50KinaseStructure–activity relationshipCytotoxicitySelectivityPharmacologyBiochemistryIn vitroBiologyCatalysisSignaling Pathways in Disease14-3-3 protein interactionsHistone Deacetylase Inhibitors Research