miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism
Lan Sun, Peirong Lin, Ying Chen, Haoying Yu, Shuyu Ren, Jingrong Wang, Liyun Zhao, Guanhua Du
Abstract
Our findings indicate the prognostic and therapeutic significance of miR-182-3p in PAH and provide a new regulatory model of the myeloid-derived miR-182-3p/Myadm/KLF4/p21 axis in PAH vascular remodeling.
Topics & Concepts
KLF4Cancer researchmicroRNAPathogenesisPathologicalTranscription factorPulmonary arteryBiologyMedicineCell biologyGenePathologyInternal medicineGeneticsSOX2Kruppel-like factors researchMicroRNA in disease regulationPulmonary Hypertension Research and Treatments