Rational Selection of CRISPR-Cas9 Guide RNAs for Homology-Directed Genome Editing
Kristina J. Tatiossian, Robert D.E. Clark, Chun Huang, Matthew E. Thornton, Brendan H. Grubbs, Paula M. Cannon
Topics & Concepts
CRISPRIndelGenome editingCas9BiologyINDEL MutationComputational biologyGuide RNAGeneticsGenomeHomology directed repairDNADNA repairGeneNucleotide excision repairSingle-nucleotide polymorphismGenotypeCRISPR and Genetic EngineeringRNA regulation and diseaseRNA and protein synthesis mechanisms