An excitatory neural circuit for descending inhibition of itch processing
Guangyan Wu, Ruo-Xuan Li, Ju Liu, Lin Sun, Yi-Lun Yi, Juan Yao, Bo-Qin Tang, Huizhong Wen, Peng-Hui Chen, Yun-Xiao Lou, Hongli Li, Jian-Feng Sui
Abstract
neurons decreases during the itch-evoked scratching period. Artificial activation or inhibition of the neural circuits significantly impairs or enhances itch processing, respectively. Thus, an excitatory neural circuit is identified as playing a crucial inhibitory role in descending regulation of itch, suggesting that it could be a potential target for treating itch.
Topics & Concepts
NeuroscienceExcitatory postsynaptic potentialAnterior cingulate cortexNeural correlates of consciousnessBiological neural networkMechanism (biology)MedicinePsychologyInhibitory postsynaptic potentialCognitionPhilosophyEpistemologyDermatology and Skin DiseasesAllergic Rhinitis and SensitizationAdvancements in Transdermal Drug Delivery