Immune-stimulating Effect of <i>Lactobacillus plantarum</i> Ln1 Isolated from the Traditional Korean Fermented Food, Kimchi
Hye Ji Jang, Hyung‐Seok Yu, Na‐Kyoung Lee, Hyun‐Dong Paik
Abstract
Ln1 (HK-Ln1) through the production of nitric oxide (NO) and pro-inflammatory cytokine achieved by inducing NF-κB and mitogen-activated protein kinase (MAPK)-signaling pathways in macrophages. HK-Ln1 showed higher NO and cytokine production compared t°Control (nonstimulated lipopolysaccharide); in addition, the expression of inducible nitric oxide synthase (iNOS) was induced through HK-Ln1treatment. The phosphorylation of IκB-α and p65 increased following treatment by HK-Ln1, which implicates IκB-α degradation and the translocation of p65 to nucleus. In addition, the phosphorylation of MAPKs, ERK 1/2, JNK, and p38 was induced following HK-Ln1 treatment.
Topics & Concepts
Nitric oxideLactobacillus plantarumLipopolysaccharideImmune systemCytokineNitric oxide synthasePhosphorylationp38 mitogen-activated protein kinasesMAPK/ERK pathwayMicrobiologyChemistryNF-κBKinaseSignal transductionImmunologyBiochemistryBiologyBacteriaLactic acidGeneticsOrganic chemistryFood Quality and Safety StudiesPharmacological Effects of Natural CompoundsSeaweed-derived Bioactive Compounds