Design, synthesis, biological assessment and <i>in silico</i> ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors
Mohamed Badawy, Eman K. A. Abdelall, El‐Shaymaa El‐Nahass, Khaled R.A. Abdellatif, Hamdy M. Abdel‐Rahman
Abstract
A novel series of benzimidazole derivatives wherein 4-(methylsulfonyl) phenyl pharmacophore attached via its C-2 position was designed and synthesized.
Topics & Concepts
PharmacophoreADMEChemistryBenzimidazoleIn silicoPharmacologyCyclooxygenaseIn vitroIn vivoDocking (animal)IsozymeStereochemistryEnzymeCombinatorial chemistryBiochemistryOrganic chemistryMedicineBiologyNursingGeneBiotechnologyInflammatory mediators and NSAID effectsSynthesis and biological activityComputational Drug Discovery Methods