Asymmetric copper-catalyzed alkynylallylic monofluoroalkylations with fluorinated malonates
Han-Yu Lu, Zi‐Han Li, Guo‐Qiang Lin, Zhi‐Tao He
Abstract
selectivity. The asymmetric propargylic monofluoroalkylation is also developed. The reliability and synthetic value of the work are highlighted by a gram-scale test and a couple of downstream transformations. Preliminary mechanistic studies unveil a negative nonlinear effect for the catalytic process.
Topics & Concepts
CopperCatalysisChemistryCombinatorial chemistryPolymer chemistryOrganic chemistryFluorine in Organic ChemistryInorganic Fluorides and Related Compounds