Evolution of VIM-1-Producing Klebsiella pneumoniae Isolates from a Hospital Outbreak Reveals the Genetic Bases of the Loss of the Urease-Positive Identification Character
Nicolas Cabanel, Isabelle Rosinski‐Chupin, Adriana Chiarelli, Tatiana Botin, Marta Tato, Rafael Cantón, Philippe Glaser
Abstract
Evolution of multidrug-resistant bacterial pathogens occurs at multiple scales, in the patient, locally in the hospital, or more globally. Some mutations or gene acquisitions, for instance in response to antibiotic treatment, may be restricted to a single patient due to their high fitness cost.
Topics & Concepts
Klebsiella pneumoniaeBiologyOutbreakMicrobiologyKlebsiellaAntibioticsGeneMultiple drug resistanceGeneticsVirologyEscherichia coliAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingInfections and bacterial resistance