Estrogen-induced epigenetic silencing of <i>FTH1</i> and <i>TFRC</i> genes reduces liver cancer cell growth and survival
Jibran Sualeh Muhammad, Khuloud Bajbouj, Jasmin Shafarin, Mawieh Hamad
Abstract
inhibited carcinogenesis in Hep-G2 cells. For the first time, our findings uncovered the novel signalling pathway involved in the protective effects of E2 against liver cancer.
Topics & Concepts
BiologyGene knockdownGene silencingEpigeneticsDNA methylationCancer researchCarcinogenesisCell growthChromatin immunoprecipitationCell biologyGene expressionCancerCell cultureGeneGeneticsPromoterCancer-related gene regulationEpigenetics and DNA MethylationRenal and related cancers