Optical Control of Phosphatidic Acid Signaling
Reika Tei, Johannes Morstein, Andrej Shemet, Dirk Trauner, Jeremy M. Baskin
Abstract
selectively inhibit this pathway. Collectively, these photoswitchable PA analogues enable optical control of mTOR and Hippo signaling, and we envision future applications of these probes to dissect the pleiotropic effects of physiological and pathological PA signaling.
Topics & Concepts
Phosphatidic acidPI3K/AKT/mTOR pathwayCell biologySignal transductionHippo signaling pathwayCell growthContext (archaeology)AzobenzeneChemistryHedgehog signaling pathwayBiologyBiochemistryPhospholipidMoleculeOrganic chemistryPaleontologyMembranePhotochromic and Fluorescence ChemistryHippo pathway signaling and YAP/TAZZebrafish Biomedical Research Applications