Human Urine Alters Methicillin-Resistant Staphylococcus aureus Virulence and Transcriptome
Santosh Paudel, Kamal Bagale, Swapnil Patel, Nicholas J. Kooyers, Ritwij Kulkarni
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is an uncommon cause of urinary tract infections (UTI) in the general population. However, it is important to understand MRSA pathophysiology in the urinary tract because isolation of MRSA in urine samples often precedes potentially life-threatening MRSA bacteremia. In this report, we describe how exposure to human urine alters MRSA global gene expression and virulence. We hypothesize that these alterations may aid MRSA in acclimating to the nutrient-limiting, immunologically hostile conditions within the urinary tract leading to MRSA UTI.
Topics & Concepts
VirulenceStaphylococcus aureusBacteremiaMicrobiologyMethicillin-resistant Staphylococcus aureusBiologyStaphylococcal infectionsUrinary systemTranscriptomeUrinePopulationMedicineAntibioticsGeneGene expressionBacteriaGeneticsBiochemistryEndocrinologyEnvironmental healthAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility TestingProbiotics and Fermented Foods