Oral Bacteriome and Mycobiome across Stages of Oral Carcinogenesis
Weiwei Heng, Wenmei Wang, Tingting Dai, Ping Jiang, Yong‐Jie Lu, Ruowei Li, Miaomiao Zhang, Ruiqi Xie, Yifan Zhou, Maomao Zhao, Ning Duan, Zhengqin Ye, Fuhua Yan, Xiang Wang
Abstract
Abundant oral microorganisms constitute a complex microecosystem within the oral environment of the host, which plays a critical role in the adjustment of various physiological and pathological states of the oral cavity. In this study, we demonstrated that variations in the "core microbiome" may be used to predict carcinogenesis. In addition, sample data collected from multiple oral sites along the health-premalignancy-carcinoma sequence increase our understanding of the microecosystems of different oral niches and their specific changes during oral carcinogenesis. This work provides insight into the roles of bacteria and fungi in OSCC and may contribute to the development of early diagnostic assays and novel treatments.