Genetics of Myelodysplastic Syndromes
Caner Saygin, Lucy A. Godley
Abstract
Myelodysplastic syndrome (MDS) describes a heterogeneous group of bone marrow diseases, now understood to reflect numerous germline and somatic drivers, characterized by recurrent cytogenetic abnormalities and gene mutations. Precursor conditions including clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance confer risk for MDS as well as other hematopoietic malignancies and cardiovascular complications. The future is likely to bring an understanding of those individuals who are at the highest risk of progression to MDS and preventive strategies to prevent malignant transformation.
Topics & Concepts
CytopeniaMyelodysplastic syndromesBone marrowSomatic cellGermlineHaematopoiesisGermline mutationSomatic evolution in cancerMedicineBioinformaticsBiologyOncologyCancer researchGeneticsMutationInternal medicineGeneStem cellAcute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesHematological disorders and diagnostics