Fine-tuning the electronic structure of heavy-atom-free BODIPY photosensitizers for fluorescence imaging and mitochondria-targeted photodynamic therapy
Sujie Qi, Nahyun Kwon, Yubin Yim, Nguyễn Văn Nghĩa, Juyoung Yoon
Abstract
We designed and investigated novel mitochondria-targeting heavy-atom-free BODIPY photosensitizers (R-<bold>BODs</bold>) that possessed considerable singlet oxygen generation abilities and good fluorescence properties for imaging-guided photodynamic therapy (PDT).
Topics & Concepts
Photodynamic therapyBODIPYSinglet oxygenFluorescencePhotochemistryChemistryMitochondrionFluorescence-lifetime imaging microscopyReactive oxygen speciesPhotosensitizerBiophysicsOxygenBiochemistryOpticsBiologyPhysicsOrganic chemistryNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies