Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations
Moataz A. Shaldam, Mai H. A. Mousa, Haytham O. Tawfik, Ahmed M. El‐Dessouki, Marwa Sharaky, Mohamed M. Saleh, Abdullah Yahya Abdullah Alzahrani, Sana Ben Moussa, Ahmed A. Al‐Karmalawy
Topics & Concepts
ChemistryAcetamideThio-In vivoIn vitroTelomeraseStereochemistryPharmacologyBiochemistryOrganic chemistryGeneGeneticsMedicineBiologyCytokine Signaling Pathways and InteractionsSynthesis and biological activityCancer therapeutics and mechanisms