Functional Analysis of Phenazine Biosynthesis Genes in <i>Burkholderia</i> spp.
Samuel Hendry, Stephan Steinke, Kathrin Wittstein, Marc Stadler, Kirsten Harmrolfs, Yetunde Adewunmi, Gyan S. Sahukhal, Mohamed O. Elasri, Linda S. Thomashow, David M. Weller, Olga V. Mavrodi, Wulf Blankenfeldt, Dmitri V. Mavrodi
Abstract
Although the production of phenazines in Burkholderia was first reported almost 70 years ago, the role these metabolites play in the biology of these economically important microorganisms remains poorly understood. Our results revealed that the phenazine biosynthetic pathway in Burkholderia has a complex evolutionary history, which likely involved horizontal gene transfers among several distantly related groups of organisms.
Topics & Concepts
PhenazineBurkholderiaBiosynthesisGeneBiologyGeneticsMicrobiologyComputational biologyBiochemistryBacteriaPlant-Microbe Interactions and ImmunityPlant Pathogenic Bacteria StudiesLegume Nitrogen Fixing Symbiosis