<i>Cucumeropsis mannii</i> seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia
Patrick Maduabuchi Aja, Chukwu D. Chiadikaobi, Peter Chinedu Agu, Boniface Anthony Ale, Onyedika Gabriel Ani, E. U. Ekpono, Hilary Akobi Ogwoni, J.N. Awoke, Patience N. Ogbu, Lucy Aja, Felix Emmanuel Nwite, Oliver Ugochukwu Ukachi, O.U. Orji, P. C. Nweke, Chinedu Ogbonnia Egwu, Ejike Ugbala Ekpono, G. O. Ewa, I. O. Igwenyi, Deusdedit Tusubira, Christian Emeka Offor, Ekenechukwu K. Maduagwuna, Esther Ugo Alum, Daniel Ejim Uti, Amobichukwu Njoku, Ayomide Victor Atoki, Chinaza Godswill Awuchi
Abstract
Abstract This study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA‐induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine dysfunctions and dyslipidemia in bisphenol‐A (BPA)‐induced male Wistar rats. Six‐week‐old 36 albino rats of 100–200 g weight were assigned randomly to six groups, which received varied doses of BPA and/or CMSO. The administration of BPA and CMSO was done at the same time for 42 days by oral intubation. The adipokine levels and lipid profile were measured in adipose tissue and plasma using standard methods. BPA induced significant ( p < .05) increases in triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices in adipose tissue and plasma, as well as a decrease in adiponectin and HDL‐C levels in Group II animals. BPA administration significantly ( p < .05) elevated Leptin levels and reduced adiponectin levels. BPA plus CMSO reduced triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices while increasing adiponectin levels and HDL‐C in adipose tissue and plasma ( p < .05). The results showed that BPA exposure increased adipose tissue as well as serum levels of the atherogenic index, triglycerides, cholesterol, coronary risk index, LDL‐C, leptin, and body weight with decreased adiponectin levels and HDL‐C. Treatment with CMSO reduced the toxicities caused by BPA in rats by modulating the body weight, adiponectin/leptin levels, and lipid profiles in serum and adipose tissue. This study has shown that CMSO ameliorates BPA‐induced dyslipidemia and adipokine dysfunctions. We suggest for further clinical trial to establish the clinical applications.