PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication
Lori A. Emert‐Sedlak, Colin M. Tice, Haibin Shi, John J. Alvarado, Sherry T. Shu, Allen B. Reitz, Thomas E. Smithgall
Topics & Concepts
Ubiquitin ligaseUbiquitinCell biologyCereblonDownregulation and upregulationBiologyTernary complexIn vivoViral replicationProtein degradationChemistryVirologyVirusGeneticsBiochemistryEnzymeGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsHIV Research and Treatment