Comparative study on the effects of the inclusion complexes of non-steroidal anti-inflammatory drugs with 2-hydroxypropyl-β-cyclodextrins on dissociation rates and supersaturation
Yukiko Oshite, Ayako Wada-Hirai, Risa Ichii, Chihiro Kuroda, Kanji Hasegawa, Ryosuke Hiroshige, Hideshi Yokoyama, Tomohiro Tsuchida, Satoru Goto
Abstract
This result suggests that the ratio deemed appropriate in solid-phase analysis may not necessarily align with it is based on the stability constant in the aqueous solution.
Topics & Concepts
SupersaturationDissociation (chemistry)ChemistryAqueous solutionDissociation constantCyclodextrinOrganic chemistryBiochemistryReceptorDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesAnalytical Methods in Pharmaceuticals