Increased lactate in AML blasts upregulates TOX expression, leading to exhaustion of CD8<sup>+</sup> cytolytic T cells.
Ying Chen, Zening Feng, Xingyi Kuang, Peng Zhao, Bingqing Chen, Qin Fang, Weiwei Cheng, Jishi Wang
Abstract
TEMRA cells and PD-1 expression, and increased perforin and granzyme B. However, no difference was found in the relapsed patients. The study presented here has established lactate as a predictive biomarker for patient response to antitumor therapies and demonstrated that targeting this gene in AML patients could be a meaningful precision therapeutic strategy.
Topics & Concepts
Lactate dehydrogenase ACD8Lactate dehydrogenasePerforinBiologyCytolysisCytotoxic T cellGranzymeBone marrowImmunologyCancer researchImmune systemIn vitroBiochemistryEnzymeCancer, Hypoxia, and MetabolismProtein Degradation and InhibitorsAcute Myeloid Leukemia Research