Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil

Hong‐Hsiang Guan, Yen‐Hua Huang, En‐Shyh Lin, Chun‐Jung Chen, Cheng-Yang Huang

2021Biochemical and Biophysical Research Communications27 citationsDOI

Topics & Concepts

Thymidylate synthaseProtein Data Bank (RCSB PDB)NucleotideEnzymeBiochemistryBiologyStructural similarityChemistryFluorouracilChemotherapyGeneGeneticsBiochemical and Molecular ResearchEnzyme Structure and FunctionCancer, Hypoxia, and Metabolism