Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
Richard Parker, Christopher J. Weir
Abstract
There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.
Topics & Concepts
Clinical trialMultiple comparisons problemComputer scienceMedicineMedical physicsStatisticsMathematicsPathologyStatistical Methods in Clinical TrialsAdvanced Causal Inference TechniquesGenetic Associations and Epidemiology