Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer
Keita Hanada, Kenji Kawada, Gen Nishikawa, Kosuke Toda, Hisatsugu Maekawa, Yasuyo Nishikawa, Hideyuki Masui, Wataru Hirata, Michio Okamoto, Yoshiyuki Kiyasu, Shusaku Honma, Ryotaro Ogawa, Rei Mizuno, Yoshiro Itatani, Hiroyuki Miyoshi, Takehiko Sasazuki, Senji Shirasawa, Makoto M. Taketo, Kazutaka Obama, Yoshiharu Sakai
Topics & Concepts
KRASCancer researchBiologyPinocytosisCancer cellGlutamineMutantCancerColorectal cancerBiochemistryCellEndocytosisGeneticsAmino acidGeneCancer, Hypoxia, and MetabolismCellular transport and secretionUbiquitin and proteasome pathways