Two-miRNA–based finger-stick assay for estimation of absorbed ionizing radiation dose
Marshleen Yadav, Sagar Bhayana, Joseph Liu, Lanchun Lu, Jason B. Huang, Ya Ma, Zahida Qamri, Xiaokui Mo, Diviya S. Jacob, Shashaank T. Parasa, Noureen Bhuiya, Paolo Fadda, Meng Xu‐Welliver, Arnab Chakravarti, Naduparambil K. Jacob
Abstract
in blood. We bridged the exposure of these patients to fractionated radiation by comparing responses after fractionated versus single acute exposure in mice. Although validation in nonhuman primates is needed, this proof-of-concept study suggests the potential utility of this assay in radiation disaster management and clinical applications.
Topics & Concepts
BiodosimetryIonizing radiationAcute Radiation SyndromeNuclear medicineAbsorbed doseMedicineRadiationRadiation doseIrradiationDosimetryBiologyPhysicsHaematopoiesisCell biologyStem cellQuantum mechanicsNuclear physicsEffects of Radiation ExposureRadiation Therapy and DosimetryCarcinogens and Genotoxicity Assessment