Application of Pauson–Khand reaction in the total synthesis of terpenes
Majid M. Heravı, Leila Mohammadi
Abstract
The Pauson-Khand reaction (PKR) is a formal [2 + 2 + 1] cycloaddition involving an alkyne, an alkene and carbon monoxide mediated by a hexacarbonyldicobaltalkyne complex to yield cyclopentenones in a single step. This versatile reaction has become a method of choice for the synthesis of cyclopentenone and its derivatives since its discovery in the early seventies. The aim of this review is to point out the applications of PKR in the total synthesis of terpenes.
Topics & Concepts
Pauson–Khand reactionTerpeneTotal synthesisChemistryOrganic chemistryStereochemistryCatalysisCatalytic Alkyne ReactionsMicrobial Natural Products and BiosynthesisSynthetic Organic Chemistry Methods