Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia
Ben Yue, Ran Cui, Ruizhe Zheng, Weilin Jin, Chenlong Song, Tianshang Bao, Ming Wang, Fengrong Yu, Enhao Zhao
Abstract
A modification-associated positive feedforward loop between ALKBH5 and NF-κB signaling is involved in generating the IM phenotype of gastric epithelial cells. Targeting the ALKBH5/ZNF333/CYLD/CDX2 axis may be a useful therapeutic strategy for gastric IM in patients with bile regurgitation.
Topics & Concepts
CDX2BiologyTranscription factorCancer researchIntestinal metaplasiaGastric acidBile acidCell biologyHomeoboxInternal medicineCancerEndocrinologySecretionBiochemistryGeneGeneticsMedicineRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation