Electrochemical-Induced Transfer Hydrogenation of Imidazopyridines with Secondary Amine as Hydrogen Donor
Jiangwei Wen, Hongyun Qin, Kelu Yan, Xiaoting Yang, Xuejun Sun, Wei Wei, Jianjing Yang, Hua Wang
Abstract
Electrochemical-induced transfer hydrogenation (TH) of N-heteroaromatic to construct biologically active functional molecule is an appealing and yet challenging task. We report herein the first selective transfer hydrogenation of imidazopyridine derivatives with secondary amines as the hydrogen donors under electrochemical conditions. The successful conversion of cathode transfer hydrogenation depends on the solvation effect. Importantly, such electrochemical-induced transfer hydrogenation can be easily amplified with excellent efficiency.
Topics & Concepts
ChemistryElectrochemistryTransfer hydrogenationAmine gas treatingCombinatorial chemistryMoleculeSolvationOrganic chemistryCatalysisElectrodePhysical chemistryRutheniumAsymmetric Hydrogenation and CatalysisAmmonia Synthesis and Nitrogen ReductionElectrocatalysts for Energy Conversion