Total synthesis: the structural confirmation of natural products
Debobrata Paul, Ashis Kundu, Sanu Saha, Rajib Kumar Goswami
Abstract
This feature article highlights total synthesis as one of the reliable tools for the structural confirmation of natural products. Even though there has been substantial improvement in spectroscopic techniques that has opened an important avenue up to the synthetic community for discoveries, the structural misassignment of natural products remains a common occurrence. Herein, we have included a few case studies, along with some selected examples of natural products associated with our current research interests, where structures were revised in recent years using the art of chemical synthesis.
Topics & Concepts
Natural (archaeology)Total synthesisFeature (linguistics)ChemistryComputer scienceBiochemical engineeringStereochemistryBiologyEngineeringPhilosophyPaleontologyLinguisticsMolecular spectroscopy and chiralityChemical synthesis and alkaloidsMicrobial Natural Products and Biosynthesis