Electrochemical Aerobic Oxygenation and Nitrogenation of Cyclic Alkenes via C═C Bond Cleavage or Oxygenation and Azidation of Open-Chain Alkenes
Yan Zhu, Cong Jiang, Heng Li, Ping Liu, Peipei Sun
Abstract
An efficient strategy involving electrochemical C═C double-bond cleavage and functionalization of cyclic alkenes for the synthesis of ketonitriles is described. This transformation features environmentally friendly conditions and utilizes relatively safe TMSN3 as the nitrogenation reagent and molecular oxygen as the oxidant. For the open-chain alkenes, the reaction gave 1,2-difunctionalized products. A wide range of cyclic alkenes and open-chain alkenes were found to be compatible, providing the corresponding ketonitriles and α-azido aromatic ketones in moderate to good yields.
Topics & Concepts
ChemistryReagentBond cleavageElectrochemistryOxygenationCleavage (geology)Environmentally friendlySurface modificationCombinatorial chemistryAlkeneOxygenOrganic chemistryCatalysisElectrodeEngineeringBiologyGeotechnical engineeringEcologyPhysical chemistryFracture (geology)Radical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques