Toxic effects of copper on the jejunum and colon of pigs: mechanisms related to gut barrier dysfunction and inflammation influenced by the gut microbiota
Jianzhao Liao, Quanwei Li, Chaiqin Lei, Wenlan Yu, Jichang Deng, Jianying Guo, Qingyue Han, Lianmei Hu, Ying Li, Jiaqiang Pan, Hui Zhang, Yung-Fu Chang, Zhaoxin Tang
Abstract
were significantly increased in the colon, with an evident impact on glycerophospholipid metabolism, retinol metabolism, and steroid hormone biosynthesis. These findings revealed that excess Cu had significant effects on the microbiota and metabolites in the jejunum and colon, which were involved in intestinal barrier dysfunction and inflammation.
Topics & Concepts
JejunumBarrier functionBiologyCecumMicrobiologyOccludinInflammationGut floraLactobacillusTight junctionBiochemistryInternal medicineEndocrinologyImmunologyCell biologyMedicineFermentationGut microbiota and healthOral microbiology and periodontitis researchBarrier Structure and Function Studies