Reprogramming Synthetic Cells for Targeted Cancer Therapy
Boon Huat Lim, Yutong Yin, Hua Ye, Zhanfeng Cui, Antonis Papachristodoulou, Wei E. Huang
Abstract
by compromising the plasma membrane of cancer cells. The cancer-killing effect can be further enhanced by an aspirin/salicylate inducible gene circuit that converts salicylate into catechol, a potent anticancer. This work highlights the potential of SimCells and mini-SimCells for targeted cancer therapy and lays the foundation for the application of synthetic biology to medicine.
Topics & Concepts
ReprogrammingCancer cellSuicide geneCancerCancer researchBiologySynthetic biologyCarcinoembryonic antigenGenetic enhancementColorectal cancerComputational biologyCellGeneGeneticsCancer Research and TreatmentsBacteriophages and microbial interactionsVirus-based gene therapy research