Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment
Saínza Lores, Manuel Gámez-Chiachio, María Cascallar, Carmen Ramos, Pablo Hurtado, Sandra Alijas, Rafael López‐López, Roberto Piñeiro, Gema Moreno‐Bueno, María de la Fuente
Abstract
approach to demonstrate the efficacy of the proposed PSN-pDNA formulation in a more complex model. Finally, intratumoral and intraperitoneal administration to mice-bearing MDA-MB-231 xenografts resulted in a significant decrease in tumour cell growth, highlighting the potential of the developed gene therapy nanoformulation for the treatment of triple negative breast cancer.
Topics & Concepts
PutrescineGeneComputational biologyChemistryCancer researchBiologyBiochemistryEnzymeRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesVirus-based gene therapy research