A modular aldol approach for internal fluorescent molecular rotor chalcone surrogates for DNA biosensing applications
Ryan E. Johnson, Makay T. Murray, Lucas J. Bycraft, Stacey D. Wetmore, Richard A. Manderville
Abstract
. The library also contains a FRET pair and dual emission probes, suitable for ratiometric sensing. The ease of aldol insertion coupled with the excellent performance of the FMR chalcones permits their future wide-spread use.
Topics & Concepts
BiosensorChalconeOligonucleotideFluorescenceDNAAldol reactionRotor (electric)Modular designCombinatorial chemistryChemistryNanotechnologyBiochemistryComputer scienceMaterials scienceStereochemistryEngineeringPhysicsCatalysisMechanical engineeringOperating systemQuantum mechanicsAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion DetectionDNA and Nucleic Acid Chemistry