Mineral waters, metabolism, neuro-endocrine-immune complex

Abstract

<strong>International Medical University, Odesa, Ukraine</strong> <strong>Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine</strong> <strong>OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine</strong> <strong>IY Horbachevskyi National Medical University, Ternopil’, Ukraine</strong> <strong>MINERAL WATERS,</strong> <strong>METABOLISM,</strong> <strong>NEURO-ENDOCRINE-IMMUNE COMPLEX</strong> <strong>Editors</strong> <strong>Igor L. Popovych</strong> <strong>Anatoliy I. Gozhenko</strong> <strong>Mykhaylo M. Korda</strong> <strong>Ivan M. Klishch</strong> <strong>Dariya V. Popovych</strong> <strong>Walery Zukow</strong> <strong>Odesa</strong><strong>, 2022</strong> <strong>International Medical University, Odesa, Ukraine</strong> <strong>Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine</strong> <strong>OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine</strong> <strong>IY Horbachevskyi National Medical University, Ternopil’, Ukraine</strong> <strong>MINERAL WATERS,</strong> <strong>METABOLISM,</strong> <strong>NEURO-ENDOCRINE-IMMUNE COMPLEX</strong> <strong>Editors</strong> <strong>Igor L. Popovych</strong> <strong>Anatoliy I. Gozhenko</strong> <strong>Mykhaylo M. Korda</strong> <strong>Ivan M. Klishch</strong> <strong>Dariya V. Popovych</strong> <strong>Walery Zukow</strong> <strong>Odesa</strong><strong>, 2022</strong> <strong>Authors</strong> <strong>Badiuk Nataliya S., MD, PhD.</strong><strong> Ukrainian Scientific Research Institute of Medicine of Transport, Odesa</strong><strong>, Ukraine</strong> <strong>[email protected]</strong> <strong>Bilas Volodymyra R., MD, PhD.</strong><strong> OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine</strong> <strong>[email protected]</strong> <strong>Gozhenko Anatoliy I., MD, DS, Prof.</strong><strong> Ukrainian Scientific Research Institute of Medicine of Transport, Odesa</strong><strong>, Ukraine</strong> <strong>[email protected]</strong> <strong>Gozhenko Olena A., MD, DS, Prof.</strong><strong> Ukrainian Scientific Research Institute of Medicine of Transport, Odesa</strong><strong>, Ukraine</strong> <strong>[email protected]</strong> <strong>Hrytsak Myroslava V., MD</strong><strong>.</strong><strong> Ukrainian Scientific Research Institute of Medicine of Transport, Odesa</strong><strong>, Ukraine</strong> <strong>[email protected]</strong> <strong>Hrytsan Ivanna I., MD, PhD.</strong><strong> International Medical University, Odesa, Ukraine </strong><strong>[email protected]</strong> <strong>Klishch Ivan M., MD, DS, Prof.</strong><strong> IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine </strong><strong>[email protected]</strong> <strong>Korda Mykhaylo M., MD, DS, Prof.</strong><strong> IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine </strong><strong>[email protected]</strong> <strong>Popovych Andriy I., MD.</strong><strong> OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine</strong> <strong>[email protected]</strong> <strong>Popovych Dariya V., MD, DS, Prof.</strong><strong> IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine </strong><strong>[email protected]</strong> <strong>Popovych Igor L., MD, PhD.</strong><strong> Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine </strong><strong>[email protected]</strong> <strong>Zavidnyuk Yuriy V., MD, PhD</strong><strong>.</strong><strong> IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine </strong><strong>[email protected]</strong> <strong>Ż</strong><strong>ukow Xawery, MS. </strong><strong>Medical University of Bialystok, Bialystok, Poland </strong><strong>[email protected]</strong> <strong>Zukow Walery, MD, PhD, DS.</strong><strong> Nicolaus Copernicus University, Torun, Poland </strong><strong>[email protected]</strong> Recommended for publication by the Academic Council of the State Enterprise Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine (Protocol No. 2 dated 23.02.2022). Reviewers: Ruslan Vastyanov, Doctor of Medical Sciences, Professor, Honored Worker of Science and Technology of Ukraine, Head of the Department of General and Clinical Physiology. V.V. Pidvysotsky Odesa National Medical University. Ivan Savitsky, Doctor of Medical Sciences, Professor, Vice-Rector for Scientific and Pedagogical Work, Head of the Department of Medical and Biological Disciplines of The Odesa International Medical University. <strong>Dedicated to the 75th anniversary of V</strong><strong>o</strong><strong>lodymyr Illich Kozyavkin</strong> <strong>with gratitude for the support of the Truskavetsian Scientific School of Balneology</strong> <strong>Mineral Waters, Metabolism, Neuro-Endocrine-Immune Complex</strong>: Моnоgraph / Badiuk NS, Bilas VR, Gozhenko AI, Gozhenko OA, Hrytsak MV, Hrytsan II, Klishch IM, Korda MM, Popovych AI, Popovych DV, Popovych IL, Zavidnyuk YV, Żukow X., Zukow W. Odesa. Feniks; 2022: 252 p. <strong>ISBN </strong><strong>978-1-4716-8247-6 </strong><strong>DOI </strong><strong>https://doi.org/10.5281/zenodo.6604298</strong> <strong>Badiuk Nataliya S., Bilas Volodymyra R., Gozhenko Anatoliy I., Gozhenko Olena A., Hrytsak Myroslava V., Hrytsan Ivanna I., Klishch Ivan M., Korda Mykhaylo M., </strong><strong>Popovych Andriy I.,</strong> <strong>Popovych Dariya V., Popovych Igor L.,</strong> <strong>Zavidnyuk Yuriy V., </strong><strong>Ż</strong><strong>ukow Xawery</strong><strong>, </strong><strong>Zukow Walery. </strong><strong>Mineral waters, metabolism, neuro-endocrine-immune complex. </strong><strong>Editors Igor L. Popovych, Anatoliy I. Gozhenko, Mykhaylo M. Korda, Ivan M. Klishch, Dariya V. Popovych, Walery Zukow. </strong><strong>Odesa</strong><strong>. </strong><strong>2022: </strong><strong>2</strong><strong>52</strong><strong> p. ISBN </strong><strong>978-1-4716-8247-6 </strong><strong>DOI </strong><strong>https://doi.org/10.5281/zenodo.6604298</strong> The monograph systematizes these writers and highlights the results of their own priority experimental and clinical-physiological studies of the impact of drinking mineral waters of Ukraine on neuroendocrine regulation, metabolism and immunity of healthy rats and patients in the process of rehabilitation of chronic pyelonephritis and cholecystitis in remission. In line with the concepts of functional-metabolic continuum and neuroendocrine-immune complex using the methods of factor, discriminant and canonical correlation analysis, it is demonstrated that mineral waters have both similar and specific physiologically favorable modulating effects on the parameters of the studied body systems. For specialists in medical rehabilitation, endocrinologists, immunologists, biochemists, pathophysiologists. <strong>ISBN </strong><strong>978-1-4716-8247-6</strong> <strong>DOI </strong><strong>https://doi.org/10.5281/zenodo.6604298</strong> © International Medical University, Odesa, 2022 © Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, 2022 © OO Bohomolets’ Institute of Physiology, Kyїv, 2022 © IY Horbachevskyi National Medical University, Ternopil’, 2022 © Authors <strong>ISBN </strong><strong>978-1-4716-8247-6</strong> <strong>DOI </strong><strong>https://doi.org/10.5281/zenodo.6604298</strong> <strong>CONTENT</strong> <strong>SUMMARY .........................................................................................</strong><strong>.........</strong><strong>...........</strong><strong>.</strong><strong>........... 9</strong> <strong>INTRODUCTION ........................................................................................</strong><strong>..........</strong><strong>........... 13</strong> <strong>CHAPTER 1 .......................................................................................................</strong><strong>.........</strong><strong>...... 1</strong><strong>5</strong> <strong>EFFECTS OF MINERAL WATERS ON METABOLISM AND NEURO-ENDOCRINE-IMMUNE COMPLEX (review)</strong> <strong>1.1. Metabolism ..................................................................................................</strong><strong>.........</strong><strong>...... 1</strong><strong>7</strong> <strong>1.2. Immune system ….......................................................................................</strong><strong>.........</strong><strong>...... 2</strong><strong>1</strong> <strong>1.3. Neuro-hormonal regulation …....................................................................</strong><strong>.........</strong><strong>..... 2</strong><strong>4</strong> <strong>1.4. Gastroentero-pancreatic endocrine system ................................................</strong><strong>.........</strong><strong>.... 3</strong><strong>3</strong> <strong>CHAPTER 2 ......................................................................................................</strong><strong>........</strong><strong>........ 3</strong><strong>7</strong> <strong>GENERAL NON-SPECIFIC METABOLIC, NEUROENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS</strong> <strong>CHAPTER 3 ..........................................................................................................</strong><strong>.........</strong><strong>... 4</strong><strong>5</strong> <strong>FEATURES OF METABOLIC REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS</strong> <strong>CHAPTER 4 ....................................................................................................</strong><strong>.........</strong><strong>......... </strong><strong>60</strong> <strong>FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS</strong> <strong>CHAPTER 5 ..................................................................................................</strong><strong>.........</strong><strong>........... 7</strong><strong>3</strong> <strong>PECULIARITIES OF INTEGRATED REACTIONS

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