Dual regulation of NEMO by Nrf2 and miR-125a inhibits ferroptosis and protects liver from endoplasmic reticulum stress-induced injury
Jihoon Tak, Min Sung Joo, Yun Seok Kim, Hyun Woo Park, Chang Hyun Lee, Gil‐Chun Park, Shin Hwang, Sang Geon Kim
Abstract
overexpression responsible for the increase of miR-125a, an unprecedented NEMO inhibitor, resulting in GPX4 induction. Accordingly, the induction of NEMO mitigates ferroptotic liver injury.
Topics & Concepts
Endoplasmic reticulumUnfolded protein responseCell biologyDownregulation and upregulationHepatocyteCancer researchBiologyGPX4Oxidative stressChemistryGeneGlutathione peroxidaseBiochemistryIn vitroCatalaseFerroptosis and cancer prognosisCircular RNAs in diseasesCancer-related molecular mechanisms research