Elevated expression of RIT1 hyperactivates RAS/MAPK signal and sensitizes hepatocellular carcinoma to combined treatment with sorafenib and AKT inhibitor
Liang-Zhan Sun, Shaoyan Xi, Zhengdong Zhou, Feifei Zhang, Pengchao Hu, Yuzhu Cui, Shasha Wu, Ying Wang, Shayi Wu, Yanchen Wang, Yuyang Du, Jingyi Zheng, Hui Yang, Miao Chen, Qian Yan, Dandan Yu, Chaoran Shi, Yu Zhang, Dan Xie, Xin‐Yuan Guan, Yan Li
Topics & Concepts
SorafenibProtein kinase BCancer researchMAPK/ERK pathwayBiologyAngiogenesisHepatocellular carcinomaSignal transductionGeneticsProtein Tyrosine PhosphatasesCancer Mechanisms and TherapyPI3K/AKT/mTOR signaling in cancer