Metal-free dearomatization reactions of naphthol-ynamides for the divergent and enantioselective synthesis of azaspirocycles
Hang‐Hao Li, Yiping Zhang, Tong‐Yi Zhai, Yang Liu, Chong‐Yang Shi, Jin‐Mei Zhou, Long‐Wu Ye
Abstract
An efficient Brønsted acid (BA) catalyzed intramolecular dearomatization cyclization of naphthol-ynamides has been developed, enabling the practical and divergent synthesis of two azaspirocycles in high yields.
Topics & Concepts
ChemistryEnantioselective synthesisIntramolecular forceMetalCombinatorial chemistryCatalysisBrønsted–Lowry acid–base theoryDivergent synthesisOrganic chemistryStereochemistryCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsChemical synthesis and alkaloids