End group chemistry modulates physical properties and biomolecule release from biodegradable polyesters
Matthew A. Borrelli, Jordan Warunek, Tarini Ravikumar, Stephen C. Balmert, Steven R. Little
Abstract
MPs and slightly accelerated from PLGA-OH MPs, compared to PLGA-COOH MPs. These studies provide further insight into the interactions between charged biomolecules and the encapsulating polymer and could provide additional tools to tune release for various protein therapeutics that experience such interactions.
Topics & Concepts
PLGAPolyesterBiomoleculeGlycolic acidEncapsulation (networking)Biodegradable polymerChemistryNanotechnologyMaterials scienceLactic acidControlled releaseChemical engineeringCombinatorial chemistryOrganic chemistryPolymerNanoparticleComputer scienceBacteriaBiologyEngineeringComputer networkGeneticsbiodegradable polymer synthesis and propertiesEnzyme Catalysis and Immobilization