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Fast Proton Transport in FeFe Hydrogenase via a Flexible Channel and a Proton Hole Mechanism

Rakesh C. Puthenkalathil, Bernd Ensing

2022The Journal of Physical Chemistry B18 citationsDOIOpen Access PDF

Abstract

formation activity and that cysteine C299 may be considered protonated at physiological pH conditions. Detailed understanding of this proton transport may aid in the ongoing attempts to design artificial biomimetic hydrogenases for hydrogen fuel production.

Topics & Concepts

Proton transportProtonProtonationHydrogenaseChemistryElectron transport chainHydrideChemical physicsMolecular dynamicsHydrogenMoleculeHydrogen bondCatalysisElectron transferProton-coupled electron transferActive siteComputational chemistryPhotochemistryStereochemistryPhysicsOrganic chemistryIonQuantum mechanicsBiochemistryMetalloenzymes and iron-sulfur proteinsElectrocatalysts for Energy ConversionHydrogen Storage and Materials
Fast Proton Transport in FeFe Hydrogenase via a Flexible Channel and a Proton Hole Mechanism | Litcius