Regioselective and stereospecific synthesis of functionalized 3,4-dihydro-2<i>H</i>-1,4-thiazines by catalyst-free [3 + 3] annulation of pyridinium 1,4-zwitterionic thiolates and aziridines
Chuan‐Chuan Wang, Yantao Yang, Qinglong Wang, Xuehua Liu, Yajing Chen
Abstract
An efficient route to 3,4-dihydro-2 H -1,4-thiazines was developed though [3 + 3] annulation of pyridinium 1,4-zwitterionic thiolates and aziridines under catalyst-free conditions.
Topics & Concepts
ChemistryPyridiniumAnnulationRegioselectivityStereospecificityCatalysisOrganic chemistryCombinatorial chemistryMedicinal chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSynthesis of heterocyclic compounds