GLUT inhibitor WZB117 induces cytotoxicity with increased production of amyloid-beta peptide in SH-SY5Y cells preventable by beta-hydroxybutyrate: implications in Alzheimer’s disease
Gourav Chandan, Upasana Ganguly, Soumya Pal, Sukhpal Singh, Reena V. Saini, Sankha Shubhra Chakrabarti, Adesh K. Saini, Sasanka Chakrabarti, Sasanka Chakrabarti, Sasanka Chakrabarti
Topics & Concepts
SH-SY5YAmyloid betaProgrammed cell deathPathogenesisGlucose transporterNeurodegenerationReactive oxygen speciesMitochondrionAlzheimer's diseaseMitochondrial permeability transition poreIntracellularChemistryBiologyPharmacologyCell cultureApoptosisCell biologyEndocrinologyNeuroblastomaBiochemistryInternal medicineMedicineDiseaseImmunologyPeptideGeneticsInsulinDiet and metabolism studiesCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer