Neurotoxicity from long-term exposure to 6-PPDQ: Recent advances
Changsheng Ma, Dong-Lun Li, Fang Wang, Jinpeng Wang, Mao-Tao He
Abstract
The recent acceleration of industrialization and urbanization has brought significant attention to N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ), an emerging environmental pollutant from tire wear, due to its long-term effects on the environment and organisms. Recent studies suggest that 6-PPDQ can disrupt neurotransmitter synthesis and release, impact receptor function, and alter signaling pathways, potentially causing oxidative stress, inflammation, and apoptosis. This review investigates the potential neurotoxic effects of prolonged 6-PPDQ exposure, the mechanisms underlying its cytotoxicity, and the associated health risks. We emphasize the need for future research, including precise exposure assessments, identification of individual differences, and development of risk assessments and intervention strategies. This article provides a comprehensive overview of 6-PPDQ's behavior, impact, and neurotoxicity in the environment, highlighting key areas and challenges for future research. • 6-PPDQ from tire wear disrupts neurotransmitter synthesis and signaling. • Explores 6-PPDQ’s cytotoxicity, focusing on oxidative stress and inflammation. • Calls for precise exposure assessments and research on 6-PPDQ health risks.