DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps
Degao Chen, Zheng Jin, Chu Han, Yucui Wu, Yangping Bian, Ting Yuan, Hao Lv, Qiuyu Xia, Lei Wang, Qian Chu, Quanxing Liu, Dong Zhou, Wenfeng Fang, Xiaoming Cheng, Haoran Zha, Haixia Long, Li Zhang, Jigang Dai, Yisong Y. Wan, Qi-Jing Li, Qingzhu Jia, Xindong Liu, Bo Zhu
Topics & Concepts
Cytotoxic T cellCD8Tumor microenvironmentCancer researchInfiltration (HVAC)Dendritic cellAdoptive cell transferT cellEffectorNeutrophil extracellular trapsImmune systemBiologyCell biologyImmunologyInflammationMaterials scienceIn vitroBiochemistryComposite materialCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune cells in cancer